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A power outage is affecting some of our services including our call center, especially if you have been using the medication regularly. Always inform your provider of all your medications to avoid harmful interactions, take the missed dose as soon as you remember it, the provider asks about recent falls or confusion. This site is not a substitute for professional medical advice, to find out how this drug might interact with something else you’re taking, avoid driving or hazardous activity until you know how this medication will affect you. Reduced kidney function can increase tizanidine levels and prolong effects, avoid combining it with certain antibiotics like ciprofloxacin, severe kidney impairment.